The main objective of the 2nd International Symposium on Retinal and Choroidal Angiogenesis is to provide an opportunity for students, residents, professors, clinicians and paramedics to familiarize themselves with the most recent advances in specific areas of ophthalmology that apply not only to age-related macular degeneration, but also to ischemic retinopathies, such in diabetes and prematurity.
Comité organisateur / Organizing committee: Sylvain Chemtob, MD, PhD, FRCPC, FAAP | Isabelle Hardy, MD, FRCS(C), DABO | Adriana Di Polo, PhD | Przemyslaw (Mike) Sapieha, PhD | Flavio Rezende, MD, PhD | Bruno Larrivée, PhD | Isabelle Lahaie, MSc | Valérie Lavastre, PhD | Annie Blais, BA | Benjamin Pellacani, BAA.
- ⏯ MOT D’OUVERTURE / OPENING SPEECH – SYLVAIN CHEMTOB, MD, PH D, FRCPC, FAAP. & EKAT KRITIKOU, PHD, VICE-DOYENNE À LA RECHERCHE ET AU DÉVELOPPEMENT À L’UNIVERSITÉ DE MONTRÉAL
- ⏯ CONFIGURATION DE L’ARBRE VASCULAIRE – RÉGULATION ENDOTHÉLIALE / SHAPING THE VASCULAR TREE – PRINCIPLES AND REGULATION OF ENDOTHELIAL BEHAVIOUR – HOLGER GERHARDT, PHD, PROFESSOR FOR EXPERIMENTAL CARDIOVASCULAR RESEARCH AT CHARITÉ, PROFESSOR AT THE GERMAN CENTER FOR CARDIOVASCULAR RESEARCH (DZHK) AND AT THE BERLIN INSTITUTE OF HEALTH (BIH), SPOKESPERSON AT THE MDC INTEGRATIVE BIOMEDICINE, HEAD OF INTEGRATIVE VASCULAR BIOLOGY, MAX-DELBRÜCK-CENTRUM (MDC) FOR MOLECULAR MEDICINE, BERLIN, GERMANY
- ⏯ LES CELLULES SOUCHES ET PROGÉNITRICES HÉMATOPOÏÉTIQUES PROVIENNENT DE DIFFÉRENTS COMPARTIMENTS DE LA MOELLE OSSEUSE EN RÉPONSE À UNE INJURE RÉTINIENNE / HEMATOPOIETIC STEM/PROGENITOR CELLS MOBILIZE FROM DISTINCT BONE MARROW COMPARTMENTS IN RESPONSE TO RETINAL INJURY – MARIA GRANT, MD, FARVO, PROFESSOR AND EIVO AND ALSTON CALLAHAN ENDOWED CHAIR, DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES, UNIVERSITY OF ALABAMA, BIRMINGHAM, ALABAMA, USA
- ⏯ LES ANGIOCRINES CORONARIENNES STIMULANT LA RÉGÉNÉRESCENCE CARDIAQUE / CORONARY ANGIOCRINES TO STIMULATE HEART REGENERATION – RUBÉN MARIN JUEZ, PHD, ASSISTANT PROFESSOR, DEPARTMENT OF PATHOLOGY AND CELLULAR BIOLOGY, FACULTY OF MEDICINE, UNIVERSITY OF MONTREAL, CENTRE DE RECHERCHE DU CHU SAINTE-JUSTINE, MONTREAL, QUEBEC, CANADA
- ⏯ CIBLER LA SIGNALISATION PATHOLOGIQUE AFIN DE RÉTABLIR L’HOMÉOSTASIE DANS LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L’ÂGE / TARGETING PATHOLOGIC SIGNALING TO RESTORE HOMEOSTASIS IN AGE-RELATED MACULAR DEGENERATION – MARY-ELIZABETH HARTNETT, MD, FACS, FARVO, DISTINGUISHED PROFESSOR OF OPHTHALMOLOGY AND VISUAL SCIENCES, CALVIN S. AND JENEAL N. HATCH PRESIDENTIAL ENDOWED CHAIR IN OPHTHALMOLOGY AND VISUAL SCIENCES, DIRECTOR OF PEDIATRIC RETINA AT MORAN EYE CENTER, ADJUNCT PROFESSOR OF PEDIATRICS AND OF NEUROBIOLOGY, JOHN A. MORAN EYE CENTER – UNIVERSITY OF UTAH, SALT LAKE CITY, UTAH, ÉTATS-UNIS
- ÉTUDES TRANSLATIONNELLES POUR LA PHASE I DE LA RÉTINOPATHIE DU PRÉMATURÉ / TRANSLATIONAL STUDIES IN PHASE I ROP – LOIS E. H. SMITH, MD, PHD, PROFESSOR, DEPARTMENT OF OPHTHALMOLOGY, HARVARD MEDICAL SCHOOL, BOSTON CHILDREN’S HOSPITAL, BOSTON, MASSACHUSSETTS, USA (Enregistrement non disponible / recording unavailable)
- MODULATION ALLOSTÉRIQUE DE VOIES INFLAMMATOIRES DANS LE TRAITEMENT DE LA DÉGÉNÉRESCENCE VASCULAIRE DE LA RÉTINE ET CHOROÏDE / ALLOSTERIC MODULATORS OF INFLAMMATORY PATHWAYS AS TREATMENTS OF RETINAL AND CHROIDAL VASCULAR DEGENRATION – WILLIAM D. LUBELL, PHD, TENURED PROFESSOR, FACULTY OF ARTS AND SCIENCES – DEPARTMENT OF CHEMISTRY, UNIVERSITY OF MONTREAL, MONTREAL, QUEBEC, CANADA (Enregistrement non disponible / recording unavailable)
- ⏯ LE RÔLE CLÉ DES VEGF DANS L’ANGIOGENÈSE OCULAIRE / THE KEY ROLE OF VEGF IN OCULAR ANGIOGENESIS – NAPOLEONE FERRARA, MD, DISTINGUISHED PROFESSOR OF PATHOLOGY, ADJUNCT PROFESSOR OF OPHTHALMOLOGY AND PHARMACOLOGY, SENIOR DEPUTY DIRECTOR FOR BASIC SCIENCES, HILDYARD ENDOWED CHAIR FOR DISEASE OF THE EYE, UCSD MOORES CANCER CENTER, SCHOOL OF MEDICINE, UNIVERSITY OF CALIFORNIA SAN DIEGO (UCSD), LA JOLLA, CALIFORNIA, USA
- ⏯ PARTICIPATION DES MINÉRALOCORTICOÏDES DANS LES PATHOLOGIES DE LA RÉTINE / MINERALOCORTICOID PATHWAY ACTIVATION IN RETINAL PATHOLOGY – FRANCINE BEHAR-COHEN, MD, PHD, OPHTHALMOLOGY PROFESSOR AT THE UNIVERSITY PARIS CITÉ, RETINA SPECIALIST AT THE COCHIN HOSPITAL, PARIS – PUBLIC ASSISTANCE FOR PARIS HOSPITALS, DIRECTOR OF THE RESEARCH TEAM PHYSIOPATHOLOGY OF OCULAR DISEASES: THERAPEUTIC INNOVATIONS, INSERM UMR1138, CENTRE DE RECHERCHE DES CORDELIERS, PARIS, FOUNDER AND CHIEF SCIENTIFIC OFFICER OF EYEVENSYS, SAS, FRANCE, CO-FOUNDER OF EARLYSIGHT, SWITZERLAND
- SÉNESCENCE CELLULAIRE, VIEILLISSEMENT ET NUCLÉOLE / CELLULAR SENESCENCE, AGING AND THE NUCLEOLUS – GERARDO FERBEYRE, MD, PHD, TENURED PROFESSOR, DEPARTMENT OF BIOCHEMISTRY & MOLECULAR MEDICINE, FACULTY OF MEDICINE, CIBC RESEARCH CHAIR ON BREAST CANCER CAUSES, UNIVERSITY OF MONTREAL, CENTRE DE RECHERCHE DU CENTRE HOSPITALIER DE L’UNIVERSITÉ DE MONTRÉAL (CHUM), MONTREAL, QUEBEC, CANADA (Enregistrement non disponible / recording unavailable)
- LA SÉNESCENCE COMME MÉCANISME DE DÉVELOPPEMENT CONTRIBUANT À LA RÉGRESSION VASCULAIRE / SENESCENCE AS A DEVELOPMENTAL MECHANISM CONTRIBUTING TO VASCULAR REGRESSION – MALIKA OUBAHA, PHD, CANADA RESEARCH CHAIR IN SENESCENCE AND VASCULAR DEVELOPMENT, PROFESSOR, DEPARTMENT OF BIOLOGICAL SCIENCES, UNIVERSITÉ DU QUÉBEC À MONTRÉAL (UQÀM), CENTER OF EXCELLENCE IN ORPHAN DISEASE RESEARCH, COURTOIS FOUNDATION (CERMO-FC), MONTREAL, QUEBEC, CANADA (Enregistrement non disponible / recording unavailable)
- ⏯ DYNAMIQUE DES NEUTROPHILES DANS L’ŒIL / VISUALIZING NEUTROPHIL DYNAMICS ON THE EYE – AJITHA THANABALASURIAR, PHD, ASSISTANT PROFESSOR, DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS, FACULTY OF MEDICINE AND HEALTH SCIENCES, MCGILL UNIVERSITY, MONTREAL, QUEBEC, CANADA
- ⏯ UNE APPROCHE ASSISTÉE AU LASER PERMET UNE LIVRAISON PRÉCISE SOUS-RÉTINIENNE DE MÉDICAMENT POUR LA TUBULOGÉNÈSE ENDOTHÉLIALE / LASER-ASSISTED TECHNOLOGIES ENABLE PRECISE SUBRETINAL DRUG DELIVERY AND SPATIALLY GUIDED ENDOTHELIAL TUBULOGENISIS – CHRISTOS BOUTOPOULOS, PHD, ASSOCIATE PROFESSOR, DEPARTMENT OF OPHTHALMOLOGY, FACULTY OF MEDICINE, UNIVERSITY OF MONTREAL, RESEARCHER, MAISONNEUVE-ROSEMONT HOSPITAL RESEARCH CENTER, MONTREAL, QUÉBEC, CANADA
- ⏯ MOT DE LA FIN / CLOSING SPEECH – SYLVAIN CHEMTOB, M. D., PH. D., F.R.C.P.C., F.A.A.P.
Le 5 novembre 2020, 134 participants se sont réunis pour assister en ligne à la première réunion satellite du Symposium international sur l’angiogenèse rétinienne et choroïdienne.
L’objectif principal de la Réunion scientifique satellite du Symposium international en angiogénèse rétinienne et choroïdienne est de donner l’occasion aux étudiants, résidents, professeurs, cliniciens et personnel paramédical l’opportunité de se familiariser avec les plus récentes avancées dans des domaines précis de l’ophtalmologie qui s’appliquent non seulement à la dégénérescence maculaire liée à l’âge, mais également aux rétinopathies ischémiques, telles dans le diabète et la prématurité.
Plus précisément, les objectifs pédagogiques de cet événement sont les suivants :
– Expliquer aux étudiants, résidents, professeurs, chercheurs et cliniciens les concepts en émergence dans le domaine de l’angiogenèse rétinienne et choroïdienne et les implications pour la pratique clinique.
– Identifier et souligner différentes études cliniques et applications cliniques contemporaines d’envergure en angiogénèse de la rétine et de la choroïde.
– Reconnaitre les altérations génétiques responsables de malformations vasculaires.
– Développer des connaissances en thérapie génique d’application ophtalmique.
– Se familiariser avec les problèmes du métabolisme de la rétine pouvant mener à la cécité.
– Découvrir le potentiel thérapeutique de découvertes scientifiques.
– Explorer les découvertes sur des maladies du système nerveux central dans le but de les appliquer dans des désordres ophtalmiques analogues.
– Favoriser les échanges d’idées sur les recherches récentes portant sur l’angiogenèse rétinienne et choroïdienne entre étudiants de tous les niveaux (stagiaires, étudiants de premier cycles, M. Sc., Ph. D., SPD, étudiants en médecine, résidents, fellows), professeurs, chercheurs et cliniciens. Ceci inclut les interactions et discussions approfondies des sujets présentés.
– Établir de nouvelles collaborations dans le but d’améliorer la compréhension des pathologies oculaires vasoproliférantes et en conséquence les soins donnés.
The main objective of the Satellite Scientific Meeting of the International Symposium on Retinal and Choroidal Angiogenesis is to provide an opportunity for students, residents, professors, clinicians and paramedics to familiarize themselves with the most recent advances in specific areas of ophthalmology that apply not only to age-related macular degeneration, but also to ischemic retinopathies, such in diabetes and prematurity.
More specifically, the educational goals of this event are as follows:
– Explain to students, residents, professors, researchers and clinicians the emerging concepts in the field of retinal and choroidal angiogenesis and implications for clinical practice.
– Identify and highlight different clinical studies and contemporary large-scale clinical applications in retinal and choroidal angiogenesis.
– Recognize genetic alterations responsible for vascular malformations.
– Develop knowledge in ophthalmic gene therapy.
– Familiarize oneself with the problems of retinal metabolism that can lead to blindness.
– Discover the therapeutic potential of scientific discoveries.
– Explore discoveries about diseases of the central nervous system with the aim of applying them to similar ophthalmic disorders.
– Promote the exchange of ideas on recent research on retinal and choroidal angiogenesis among students at all levels (trainees, undergraduate, PhD, Post-Doc trainees, medical students, residents, fellows), professors, researchers and clinicians. This includes in-depth interactions and discussions of the topics presented.
– Establish new collaborations with the aim of improving the understanding of vasoproliferatives ocular pathologies and consequently the care given.
Revivez ou découvrez les présentations des 5 prestigieux invités:
(Le visionnement des conférences en différé ne donne pas le droit à des crédits.)
Mot de bienvenue – Dr Sylvain Chemtob, M.D., Ph. D., Université de Montréal, Canada
Noncanonical TGFb Signaling is Crucial for Specialized Neuroretina Tip-Cells Sprouting and Blood-Retina Barrier Formation – Alexandre Dubrac, Ph. D., Université de Montréal, Canada
Assistant Professor, Faculty of Medicine, Department of Pathology and Cell Biology, University of Montreal
Researcher, Centre de recherche du Centre hospitalier universitaire Sainte-Justine
Le Dr. Alexandre Dubrac a obtenu son doctorat à l’Université de Bordeaux I, où il a travaillé avec le Professeur Andreas Bikfalvi sur l’angiogénèse tumorale. Il s’est ensuite joint comme chercheur postdoctoral au groupe du Professeur Anne Eichmann à la Yale School of Medicine où il a exploré la fonction des régulateurs de guidance axonale lors du bourgeonnement des vaisseaux sanguins. Entre d’autres, ses travaux ont démontré la nouvelle fonction de Slit2 et Robo1&2 dans la néovascularisation de la rétine. Il a été chercheur associé à l’Université Yale, ou ses travaux ont porté sur l’interaction cellule entothéliale-péricyte au cours du développement vasculaire et de la rétinopathie ischémique. Le Dr. Dubrac a rejoint le CHU st-Justine en tant que chercheur adjoint sous octroi à l’Université de Montréal en 2018 et son laboratoire s’intéresse à identifier de nouveaux mécanismes régulant l’angiogenèse de la rétine et du cerveau lors du développement et dans des pathologies ischémiques.
Contributions of Neurovascular Abnormalities to Autism Spectrum Disorders – Baptiste Lacoste, Ph. D., Université d’Ottawa, Canada
Assistant Professor, Faculty of Medicine, Department of Cellular & Molecular Medicine, University of Ottawa
Scientist, The Ottawa Hospital Research Institute, Neuroscience Program,
University of Ottawa Brain and Mind Research Institute
My research background in neuroscience and postdoctoral training in vascular biology allow me to bridge the gap between these two disciplines, through a solid foundation in anatomical, physiological, biochemical and genetic approaches. I have developed a unique expertise focused on elucidating mechanisms of cerebrovascular plasticity and neurovascular interactions in health and disease. The brain, which is highly dependent on a steady supply of oxygen and nutrients from the blood stream, is particularly vulnerable to inherited or acquired cerebrovascular conditions. In this context, research goals from my lab include investigating:
1) How cerebrovascular networks develop;
2) What mechanisms underlie their plasticity;
3) How vascular integrity and function are altered in neurological conditions; and
4) How targeting cerebrovascular plasticity may offer therapeutic options throughout life. Identifying key cellular and molecular mediators of cerebrovascular health is an essential pre-requisite for developing novel therapeutic strategies.
Brain arteriovenous malformations: genetic origin, signaling and potential therapies – Ivan Radovanovic, M. D., Ph. D., FMH – University of Toronto
Associate Professor, Division of Neurosurgery, Toronto Western Hospital
University Health Network and University of Toronto
Scientist, Toronto Western Research Institute
Dr. Ivan Radovanovic joined the Toronto Western Hospital as of January 2013. Dr. Radovanovic obtained his medical degree and began neurosurgery residency training at the University of Geneva, Switzerland in 1998. In 2002, he completed a diploma in molecular biology and genetics from the University of Zurich, and in 2003 he completed the equivalent of a PhD at the Institute of Neuropathology at the University of Zurich. He subsequently resumed residency training at Geneva University Hospitals, graduating from the program in 2007. In 2008, Dr. Radovanovic joined Toronto Western Hospital as a clinical fellow in neuro-oncology/skull base surgery and then also completed a clinical fellowship in cerebrovascular surgery. Between 2010-2011, Dr. Radovanovic was staff neurosurgeon at Geneva University Hospitals, Department of Clinical Neurosciences, Division of Neurosurgery. In 2013, he was recruited to the Division of Neurosurgery with a staff appointment at Toronto Western Hospital. He is currently an Assistant Professor in the Department of Surgery at The University of Toronto. His research is focused on the surgical management of ruptured and unruptured aneurysms, AVMs and dural arteriovenous fistulae, using minimally invasive techniques such as supraorbital and lateral supraorbital craniotomies. His research laboratory is within the Toronto Western Research Institute and focuses on the developmental signaling and genetics of cerebral arteriovenous malformations and brain tumors.
Metabolism of the visual cycle and the activity of lecithin retinol acyltransferase from the retinal pigment epithelium, Dr Christian Salesse, Ph. D., Université Laval, Canada
Tenured Professor, Department of Ophthalmology and Otolaryngology / Head and Neck Surgery, Université Laval
Director of Research, Department of Ophthalmology, Université Laval
Researcher, Centre universitaire d’ophtalmologie du Centre de recherche du CHU de Québec, Université Laval, Hôpital St-Sacrement
After his graduate studies in biophysics at Université du Québec à Trois-Rivières (UQTR), Christian Salesse was a postdoctoral fellow at the Johannes Gutenberg Universität in Mainz (Germany). He then became an assistant professor at UQTR in 1990 and full professor in 1998. He moved to the Université Laval in 2002 as the head of the ophthalmology research unit at the Centre de recherche du CHUL as well as the head of research of the department of ophthalmology. He was a Junior 1, Junior 2, Senior and National FRQS research fellow between 1990 and 2006. He moved to the Hôpital du St-Sacrement of the Centre de recherche du CHU de Québec-Université Laval in 2011 as the head of the theme Santé de la vision until 2018. He was an invited professor for various periods of time at several universities (Montpellier, Rennes and Bordeaux in France, Lisbon in Portugal, Changchun in China).
First Good News of 2020: Gene Therapy in Retinopathies – Dr Flavio Rezende, M.D., Ph. D., Université de Montréal, Canada
Clinical Associate Professor, Department of Ophthalmology, University of Montreal
Ophthalmologist and Surgeon Retinologist, Centre universitaire d’ophtalmologie, Hôpital Maisonneuve-Rosemont Hospital
As an Associate Professor from the Department of Ophthalmology, University of Montreal (UdeM), I lead the clinical/surgical side of our translational research team at the Centre Universitaire d’Ophtalmologie, Maisonneuve-Rosemont hospital (CUO-HMR), Montreal, Quebec, Canada. My main focus is on surgical management of complicated vitreoretinal diseases, academic teaching, and surgical translational research.
As a vitreoretinal surgeon, I have been developing and improving complex vitreoretinal surgical techniques to manage vitreoretinal diseases.
On the academic side, I have been in charge of the Vitreoretinal Fellowship Program from the Retina Service, Department of Ophthalmology, UdeM for 5 years (2013-2018).
As a surgical translational researcher, I have developed surgical techniques to obtain vitreous biopsies in an ambulatory setting, providing instrumental material for our Neuro-Vascular Biology Research Unit. We are currently building a biobank for vitreous and aqueous humor samples.
For the past 5 years, I have been involved with Retinal Chip implant, developing an innovative surgical technique for a new generation retinal chip.
And in the past year I have served as Clinical Director at CUO-HMR and, as such, I have been committed to bringing further innovation to benefit our patients. We are becoming now one of the first centers in Canada for gene therapy for previously untreatable retinal conditions.
Mot de la fin – Dr Sylvain Chemtob, M.D., Ph. D., Université de Montréal, Canada