Réunions scientifiques mensuelles

Au cours de chaque année académique, le département d’ophtalmologie organise, une série de 9 réunions scientifiques. L’objectif est de partager avec toute la communauté de l’ophtalmologie, des présentations de haut calibre, données par des spécialistes tant locaux qu’internationaux, invités à tour de rôle par les chefs de divisions.

Comité organisateur: Dr Patrick Hamel, professeur agrégé de clinique et chef du département d’ophtalmologie du CHU Saint-Justine & Dre Isabelle Hardy, directrice du département de l’Université de Montréal.

Le département remercie l’Association des Médecins Ophtalmologistes du Québec pour son soutient financier.

Calendrier des prochaines réunions: cliquez ici.

*** Le visionnement des conférences en différé ne donne pas le droit à des crédits ***

20 octobre 2020 Oculoplastie
Bench to Bedside: Evolution of Therapy for Thyroid Associated Ophthalmopathy
Présenté par Dr Terry Smith (Kellogg Eye Center)
Biographie

Terry J. Smith, M.D.
Frederick G.L. Huetwell Professor of Ophthalmology and Visual Sciences
Professor, Department of Internal Medicine
Kellog Eye Center
University of Michigan

Biography
Dr. Terry J. Smith, the Frederick G.L. Huetwell Professor in Ophthalmology and Visual Sciences at the University of Michigan, is an internationally-known endocrinologist who has studied Graves’ disease, its eye manifestations, and related autoimmune disease for over 20 years. Dr. Smith’s laboratory was first to describe the unique molecular attributes of tissue surrounding the eye that make it susceptible to inflammation in Graves’ disease. He has identified a novel autoantibody that binds to and activates a specific receptor, resulting in an exaggerated autoimmune response. His investigation of these mechanisms has yielded several potential therapeutic targets that may interrupt the disease process. These will provide the focus for future clinical trials.

Dr. Smith received his medical degree from the University of Missouri School of Medicine and completed his residency at the University of Illinois in Chicago and Sinai Hospital in Baltimore. He has completed fellowships in biophysics at the University of California School of Medicine, San Francisco, in molecular biochemistry at Columbia University in New York, and clinical endocrinology at the Pritzker School of Medicine, University of Chicago.

Dr. Smith is the author of over 150 articles and book chapters, and has been awarded five patents for his research discoveries. He has been elected to the Orbit Society, is chief scientific officer for the National Graves’ Foundation, and serves as reviewer for numerous scientific journals. Dr. Smith has been funded continuously by the National Institutes of Health and the Veterans Administration since 1983.

Areas of Interest

Research Areas
Clinical Trials – Eye Plastics

Research Summary
Autoimmune thyroid disease, extracellular matrix, cell signaling, gene expression, ecosanoids, inflammation and cytokine action

Dr. Smith’s laboratory group is interested in understanding and developing new treatments for Graves’ Disease (GD) or thyroid-associated ophthalmopathy (TAO).

Graves’ Disease is an autoimmune process directed primarily at the thyroid. Many of the patients with GD also exhibit inflammation of the tissues around the eye. Orbital manifestations of GD known as TAO, involve the dramatic remodeling of connective tissues surrounding the eye. Alterations in orbital tissue architecture can adversely affect the function and health of the eye in several ways.

  • They can deprive the globe of normal irrigation and eyelid coverage, leading to chronic irritation and infection.
  • They can compromise the ability of the eyes to move in a coordinated fashion, restricting motility, and resulting in disconjugate gaze and diplopia.
  • They can cause cosmetic changes that sometimes exert a profoundly deleterious impact on the psychological health of afflicted patients.
  • They can threaten eye sight by compressing the neuro-vascular supply to the eye.

There are no specific safe and effective therapies for TAO. Our overall goal is to identify the molecular and cellular mechanisms responsible for the pathogenesis of orbital involvement in TAO. We have found that patients with TAO have dramatically increased numbers of circulating fibrocytes. These fibrocytes derive from stem cells originating in the bone marrow. They infiltrate the connective tissues of the orbit. We believe that the phenotypic attributes of orbital fibroblasts underlie the propensity of the tissues surrounding the eye to become involved in GD. As a direct consequence of identifying the peculiarities exhibited by these cells, we are now in a strong position to create strategies for interrupting the disease process at a very early stage.

Their work is focused on defining the molecular targets that will lead to effective and specific therapy design.

Clinical Interests

Graves’ disease, thyroid-associated ophthalmopathy, metabolic diseases

Specialties: Endocrinology, Internal Medicine

Honors & Awards

2018

  • Merit Award, University of Missouri School of Medicine
  • Clinical Trial, A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, Multicenter Study Evaluating Teprotumumab (HZN-001) Treatment in Subjects with Active Thyroid Eye Disease (OPTIC) – INC Research/Horizon Pharma USA, Inc.

2017

  • River Vision Pilot Study; River Vision

Credentials

  • Medical School – University of Missouri School of Medicine, 1975
  • Residencies
    • Department of Medicine, University of Illinois, Chicago, IL, 1976
    • Department of Medicine, Sinai Hospital, Baltimore, MD, 1977
  • Fellowships
    • Biophysics, Cardiovascular Research Institute, University of California School of Medicine, San Francisco, CA, 1978
    • Biochemistry, Columbia University, New York, NY, 1979
    • Endocrinology, Pritzker School of Medicine, University of Chicago, Chicago, IL, 1981

Published Articles or Reviews
View a list of publications on Michigan Experts

Source = https://medicine.umich.edu/dept/ophthalmology/terry-j-smith-md

15 septembre 2020 Cornée et segment antérieur
Cataract Surgery in Patients with Corneal Disease: Pearls and Pitfalls.

Présenté par Dr Anthony J. Aldave (UCLA)

Biographie

Anthony J. Aldave, M.D.
Professor of Ophthalmology
Walton Li Chair in Cornea and Uveitis
Chief, Cornea and Uveitis Division
Director, Cornea and Refractive Surgery Fellowship
The Stein Eye Institute

Anthony J. Aldave, MD, received his medical degree from the University of Texas Medical Branch in Galveston. He performed his residency training in ophthalmology at the Wills Eye Hospital, Thomas Jefferson University, in Philadelphia, Pennsylvania.  Dr. Aldave then completed a two-year Cornea, Uveitis and Refractive Surgery Fellowship at The University of California, San Francisco/ Francis I. Proctor Foundation.  He joined the Stein Eye Institute in July 2002 as a full-time member of the Cornea and Refractive Surgery Services.  Dr. Aldave is currently a Professor of Ophthalmology, holds the Walton Li Chair in Cornea and Uveitis, is Chief of the Cornea and Uveitis Division and Director of the Cornea and Refractive Surgery Fellowship Program.

Dr. Aldave has received numerous honors during his career, including the Alpha Omega Alpha Scholarship Award for graduating first in his medical school class, the Heed Ophthalmic Foundation Fellowship, the American Ophthalmological Society-Knapp Testimonial Fund Fellowship, the first Claes Dohlman Society Award, and the Achievement, Secretariat and Senior Achievement Awards from the American Academy of Ophthalmology.

In addition to his busy clinical practice, Dr. Aldave directs the Corneal Genetics Laboratory at the Stein Eye Institute.  Dr. Aldave’s laboratory research focuses on the molecular genetics of the corneal dystrophies, a group of inherited disorders that affect corneal clarity and constitute one of the primary indications for corneal transplantation.  Recognized as a leader in his chosen field of scientific investigation, Dr. Aldave has authored over 150 peer-reviewed scientific publications, has been invited to give almost 450 scientific presentations at local, national and international meetings and serves as a scientific reviewer for 19 ophthalmology and genetics journals.

9 juin 2020 Cornée et segment antérieur
La chirurgie de la cataracte bilatérale simultanée.

Présenté par Dre Marie-Ève Légaré (Université Laval)

Biographie