Mark Richard Lesk

Etudes qui explore la signification des proprietes biomechaniques de l'oeil dans le development et le progression de glaucome. Development de nouvelles technologies d'imagerie de l'oeil et pour mesurer les proprietes biomechaniques et vasculaires de l'oeil.  Etudes sur le development de "Space-Associated Neuro-ocular Syndrome" chez les astronauts de NASA (Laboratoire a Johnson Space Center). Etudes sur les cellules souches dans le regenerescence de la system de drainage de l'oeil en glaucome experimentale. Development de la therapie Genique pour le glaucome avec technologie CRISPR. Etudes cliniques et experimentaux.

Subventions: 

• CIHR
• NASA/Canadian Space Agency
• NSERC
• FRQS Vision Health Research Network
• Glaucoma Research Society of Canada

Médecin ophtalmologue, le docteur Mark Lesk est Directeur de l'Unité de Recherche en Glaucome de la Centre de Recherche de l'Hôpital Maisonneuve-Rosemont. Il est également Professeur Titulaire au Département d'ophtalmologie de l'Université de Montréal, et Ophtalmologiste Chef de la Centre Universitaire d'Ophtalmologie de Universite de Montreal, a l'Hôpital Maisonneuve-Rosemont.

• Fellowship (glaucome):Wills Eye Hospital, Philadelphie

• Ophthalmology: Université de Montréal

• Doctor of Medicine: McGill University

• MSc: Weizmann Institute of Science, Israel

• 06-12-2006 Nouvelle percée dans le dépistage du glaucome

Brevet

• Lesk, MR,  Wajszilber, M, et Ozaki, T. Apparatus and Method for Measuring a Biomechanical Property of an in vivo Eye, and Method of Diagnosis. World Wide Patent application, May, 2008.

• Ocular Biomechanical Responses to Long-Duration Spaceflight. M. M. Solano, R. Dumas, M. R. Lesk and S. Costantino. IEEE Open Journal of Engineering in Medicine and Biology, vol. 6, pp. 127-132, 2025, doi:10.1109/OJEMB.2024.3453049.

• The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity. Sayah DN, Descovich D, Costantino S, Lesk MR. Ophthalmol Sci. 2024 Jul 18;4(6):100576. 2024 Nov-Dec.PMID: 39253552.

• Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study. Masís Solano M, Richer E, Costantino S, Lesk MR. Bioengineering (Basel). 2024 Apr 23;11(5):PMID: 38790278.

• Ocular rigidity and choroidal thickness changes in response to microgravity: A case study. Masís Solano M, Bélanger Nzakimuena C, Dumas R, Lesk MR, Costantino S. Am J Ophthalmol Case Rep. 2023 Oct 7;32:101940. eCollection 2023 Dec.PMID: 37860670.

• Variable phenotypic expression of MYOC mutations in a family with inherited pediatric glaucoma. Mullie GA, Javidi S, Soucy JF, Lesk MR, Hamel P. Can J Ophthalmol. 2023 Dec;58(6):e269-e270. Epub 2023 May 27.PMID: 37247815.

• Ocular Rigidity and Current Therapy. Sayah DN, Lesk MR. Curr Eye Res. 2023 Feb;48(2):105-113. Epub 2022 Jul 6.PMID: 35763027 Review.

• The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma. Sayah DN, Mazzaferri J, Descovich D, Costantino S, Lesk MR. Invest Ophthalmol Vis Sci. 2020 Nov. 2;61(13):11. PMID: 33151280.

• Non-invasive in vivo measurement of ocular rigidity: Clinical validation, repeatability and method improvement. Sayah DN, Mazzaferri J, Ghesquière P, Duval R, Rezende F, Costantino S, Lesk MR. Exp Eye Res. 2020 Jan;190:107831. Epub 2019 Oct 10.PMID: 31606450.

• Neuroretinal Rim Area Change in Glaucoma Patients With Visual Field Progression Endpoints and Intraocular Pressure Reduction. The Canadian Glaucoma Study: 4.Malik R, O, Leary N, Mikelberg FS, Balazsi AG, LeBlanc RP, Lesk MR, Nicolela MT, Trope GE, Chauhan BC; Canadian Glaucoma Study Group.Am J Ophthalmol. 2016 Mar;163:140-147. Epub 2015 Dec 17.PMID: 26705093.

• Manuguerra-Gagné R, Boulos PR, Ammar A, Leblond FA, Krosl G, Pichette V, Lesk MR, Roy DC. Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment. Stem Cells. 2013 Jun;31(6):1136-48.
• Freeman EE, Roy-Gagnon MH, Descovich D, Massé H, Lesk MR. The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, an dchoroidal blood flow pulsatility. PLoS One. 2013;8(1)
• Wang J, Freeman EE, Descovich D, Harasymowycz PJ, Kamdeu Fansi A, Li G, Lesk MR. Estimation of ocular rigidity in glaucoma using ocular pulse amplitude and pulsatile choroidal blood flow. Invest Ophthalmol Vis Sci. 2013 Mar 7;54(3):1706-11.